Can I file taxes under the same business profile two small business, self-employment, and W2s? Do I need to create multiple profiles and then Turbotax merge them?

If you are asking, can you file one tax return with W-2s and two businesses?, the answer is yes.  You only need one login and you will select that you have W-2 income and business income (self-employment income) under the Wages & Income Section.

Follow the instructions below to enter your business income:

1. Launch TurboTax
2. In the search bar at the top, enter  Schedule C
3. Select Jump to Schedule C
4. Answer Yes on the next screen - Did you have any self-employment income or expenses?
5. Answer the questions on each screen, when you get to the screen - Let's enter the income for your work, select the type of income and Continue
6. Enter your income 
7. Continue going through the screens to enter your expenses.

For additional information, review the TurboTax help articles: How does my side job affect my taxes? and How do I report income from self-employment?