I have always used Home & Business (CD). This year, I need to file a 1099-S for the sale of inherited land. TT says I need to use Premier instead. Will Premier handle my business?

You can report the 1099-S for the inherited land sale using Home and Business. You do not need to use Premier which is an Online Program. 

Here are the instructions to enter the sale of the inherited land that was reported on the 1099-S.

To enter the 1099-S in TurboTax Online:

Click on Federal > Wages & Income

1. In the Investment Income section click on the Start/Revisit box next to Stocks, Mutual Funds, Bonds, Other.  If you have already entered some investment sales, you will see a screen Here's the investment sales info we have so far.  Click on the Add More Sales link. 
2. If you haven't yet entered some investment sales, you will see a screen Did you sell any investments in 2022?  Click the Yes box.
3. On the Did you get a 1099-B or a brokerage statement for these sales? screen, Select No.
4. On the Tell us about this sale screen, select I’ll enter one sale at a time, and enter Inherited land in the Description box
5. Enter the requested information and click Continue when done

• Description -  general location or address
• Date sold -1099-S
• Date acquired - from your records
• Sale proceeds - 2099-S
• Cost basis - FMV plus expenses of the sale

You will need to determine the cost basis for the land.

If the sale was within a short time after the death of the person who had owned the land, then use the sales price as the FMV for the cost basis.  If there was a time gap you may need to do a little research to find the cost basis.  You can always use the tax assessors' figures which tend to be a bit on the lower side ( thus creating taxable profit for the inheritors ) or get a realtor familiar with the neighborhood to give you an estimate.

Please see this from the IRS about inherited property where they discuss your basis in the property at the beginning of the answer.