My wife's principle business code for doterra won't work in Turbotax. Online it says it is Principal Business Code for direct sales is 454390 - Non Store Retailers.

Use 454300. 

The IRS changed the list of principal business codes for 2022 tax returns. Code 454390 has been eliminated. TurboTax is using the IRS list for 2022.

The updated IRS chart says that for direct sales you should use the code for retailers of the primary type of product that you sell. It would be the same code that you would use if you had a bricks-and-mortar store selling the same products. In other words, you use a code representing the type of products being sold, rather than the sales channel. For example, if you primarily sell clothing you would use 458110 Clothing & clothing accessories retailers.

For doTERRA I would suggest 456190 Other health & personal care retailers.