Can you claim hormone therapy

It depends on the reason for the therapy. Hormone therapy isn't specifically listed in Publication 525 as being allowed, or not allowed as a deduction, so we need to rely on the general guidelines. 

The IRS defines deductible medical expenses as:  

"Medical expenses are the costs of diagnosis, cure, mitigation, treatment, or prevention of disease, and for the purpose of affecting any part or function of the body. These expenses include payments for legal medical services rendered by physicians, surgeons, dentists, and other medical practitioners. 

Medical care expenses must be primarily to alleviate or prevent a physical or mental disability or illness. They don't include expenses that are merely beneficial to general health, such as vitamins or a vacation."

If the therapy is prescribed or recommended by a licensed physician to treat a physical or mental disability or illness, it's deductible. 

If the therapy is just to increase general wellness, or isn't administered by a licensed medical practitioner, it's not deductible.