How do I pay social security and medicare taxes from my 1099 misc, income?

When you receive a 1099-MISC for earned income, this is reported on Schedule C, where you list the income and the expenses related to your "business" (you are in the business of providing whatever services you were providing to get the 1099-MISC).

When you complete the Schedule C, TurboTax also automatically completes Schedule SE (Self-employment). This schedule calculates your self-employment taxes based on the net profit of your Schedule C.

These self-employment taxes are the same as the Social Security and Medicare taxes that you and your employer pay when you are an employee.

These SE taxes are added to your tax due or decrease your refund - no need to make a separate filing.