You can only do the home sale exclusion every two years, so if you have not sold a home in several years, you have not used the home sale exclusion and would qualify to use it this time. And yes, you can exclude up to $500K of GAINS every 2 two years. As long as your cost basis of the home was more than 250K, you should be able to exclude all of the gains on the sale.
Go through the home sale section in TurboTax and you should get a message that there is NO capital gains tax on the sale after entering the details of the sale and confirming you meet the requirements (TurboTax will ask you how long you lived there and if you have used the exclusion in the last two years).
Search for home sale in TurboTax to be taken to the correct spot to enter a sale of a primary home. You should answer Yes on the following screen.
