There is not an entry page for the actual form 1099-S, but you can enter all of the information into the TurboTax Home Sale page/interview. Search for home sale and use the Jump to home sale link.
You won't pay taxes on the first $250,000 (also known as a gain) you make from the sale of your home (or the first $500,000 if you're Married Filing Jointly). That income is free and clear as long as:
You owned the home.
It was your main home for two years or more within the five years leading up to the sale.
You waited at least two years between selling your primary home and excluding your first $250,000 or $500,000 from taxes. In other words, you may buy and sell as many primary homes as you'd like, but you'll only get this tax benefit every two years.