Thank you for choosing TurboTax. Yes you can claim interest paid out from business credit card while filling in your expenses on T2125 Self-Employment form. When you operate a business, you often have to borrow money to buy equipment, support operations or finance expansion. You may take up a line of credit, get a loan or put expenses on your credit cards. You can deduct the interest charged on these funds from the business income, and if the business takes a loss, from any other income you may have. All interest your business pays to finance its operations is usually deductible.